Description
The dependence of biological effectiveness on energy is an unresolved question in evaluating the risk of human cancer from exposure to low linear-energy transfer (LET) radiation (i.e., photons and electrons). This dependence is relevant for estimating the level of cancer risk from exposure to low-LET radiation at lower energies in mammography, other medical imaging procedures, and various other occupational and public radiation exposures. The National Academies/National Research Council, in a 2006 report, indicated that the biological effectiveness of lower-energy low-LET radiation based on chromosomal aberration data and biophysical considerations may be two or more times greater than for higher-energy low-LET radiation. However, the biological systems used in the experiments and the biophysical analysis provide only indirect evidence and may not be strictly applicable to human cancer. Therefore, the assessment in this Report was undertaken.
This report draws on evaluation by specialists in microdosimetry, deoxyribonucleic acid (DNA) damage, cellular radiobiology, animal studies, and human epidemiology of the available evidence relevant to the variation in biological effectiveness regarding the risk of human cancer for low-LET radiation at lower energies. Probability density functions (PDFs) will be derived for the biological effectiveness observed for the endpoints studied in each specialty area (line of evidence) for defined lower-energy groups. Using these PDFs and evaluation of the relevance of the data from each line of evidence to the risk of cancer in humans, guidance will be provided on the biological effectiveness regarding the risk of human cancer of low-LET radiation for the defined lower-energy groups.
Goal
Provides guidance for the assessment of cancer risks for low-LET radiation (i.e., photon and electrons) over defined lower-energy groups.
2016 Accomplishments
- March 31, 2016: Complete draft (dated March 25) sent to all members in preparation for producing the PAC 6/expert review draft
- May 31, 2016: Draft distributed for PAC 1/expert review
- September 30, 2016: Draft being revised based on the PAC 1/expert review comments and being readied for Council review and approval
Prior Accomplishments
- January 30-31, 2013 … first full committee meeting Agreed to draft sections for the following lines of evidence: microdosimetry, DNA damage, cellular radiobiology, animal studies, human epidemiology
- September 26-28, 2013 … second full committee meeting; agreed to the following lower-energy groups: Photons of energy 1.5 keV: energy range where RBE has been observed to increase the most in experimental studies
- Delay in SC 1-20 effort pending continued financial support
- December 3-4, 2015 … third full committee meeting Reviewed consolidated draft (dated November 20)
Agreed to develop probability distribution functions (PDFs) for specific lower-energy groups
Agreed to use photons (0.5 to 2 MeV) as the reference radiation
Electrons produced by beta decay of tritium (H3): average energy (5.7 keV)
Photons of energy 15 to 30 keV: relates to mammography
Photons of energy 40 to 60 keV: relates to computed tomography
Photons of energy >60 to 150 keV: relates to orthovoltage x rays
Discussed analysis of the literature data for each line of evidence
Discussed PDFs for each line of evidence for each lower-energy group
Conducted elicitation procedure to evaluate the PDF (for each lower-energy range) for a factor relating to enhancement of risk as a function of photon/electron energy that may apply to human cancer
Generated a list of potential expert reviewers
Scheduled Activities
- First quarter 2017: Distribution of draft for Council review and approval (six week review period)
- Second quarter 2017: Publication of final report
Support
Membership
![]() STEVEN L. SIMON![]() received a BS in Physics from the University of Texas, an MS in Radiological Physics from the University of Texas Health Sciences Center in Dallas, and a PhD in Radiological Health Sciences from Colorado State University. Early in his career, he worked in medical physics and was the first treatment planner for clinical trials of treatments of solid tumors with negative pi-mesons at the Los Alamos Physics Meson Facility. Later specializing in environmental radioactivity, he directed the first nationwide monitoring program of the Marshall Islands for residual contamination from nuclear testing. He also participated in the radiological monitoring of numerous other nuclear test sites worldwide including Johnston Island, French Polynesia, and Algeria and has lead, or participated in, health risk studies of fallout exposures in Utah, the Marshall Islands, and Kazakhstan. In 2000, Dr. Simon joined the National Cancer Institute's Radiation Epidemiology Branch as an expert in dose reconstruction and presently heads the Dosimetry Unit in that group. Steve is a member of NCRP and has been an Associate Editor of Health Physics for 20 y. In 2011 during the Fukushima crisis, Steve was deployed by the U.S. Department of Health and Human Services to the U.S. Embassy in Japan to assist with the protection of American citizens. |
![]() LESLIE A. BRABYhas been a Research Professor at Texas A&M University since 1996. His previous experience includes Biology and Chemistry Department Staff Scientist from 1971 to 1991 and Radiation Physics and Chemistry Section Manager from 1991 to 1995 at Battelle, Pacific Northwest National Laboratory. He received his BA degree from Linfield College and PhD from Oregon State University in 1972. Dr. Braby is a former member of the NCRP Board of Directors and a member of several NCRP scientific committees (SC) including SC 88 on Fluence as a Basis of a System of Radiation Protection for Astronauts, SC 1-7 on Research Needs for Deep Space Missions, chair of SC 1-11 on Safety Considerations for Pulsed Fast Neutron Surveillance Systems, SC 6-1 on Uncertainties in Measuring External Beam Irradiation, SC 1-20 on the biological effects of low energy x rays, and Chairman of SC 6-5 on Safety of Cargo Inspection Systems Using High Energy Photons. He was also Chair of the International Commission on Radiation Units and Measurements (ICRU) working committee on characterizing low level radiation exposure, and member of ICRU working committee to prepare a report on microdosimetry.
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![]() Dudley T. Goodhead
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![]() Stephen C. Hora
Dr. Hora is a prominent decision analyst who has led several CREATE studies and is an experienced academic leader who served as the University of Hawaii-Hilo's Interim Vice Chancellor for Academic Affairs from 2005 to 2007. He is a Professor of Management Science and Statistics at UH-Hilo. Hora earned both his DBA and his BS from USC. |
![]() DAVID C. KOCHER![]() has extensive experience in areas of environmental health physics and assessments of dose and risk from exposure to ionizing radiation. He has special expertise in evaluations of dose and risk assessment models for regulatory and decision-making purposes, and he has written and lectured extensively on the issue of "risk harmonization" in regulating radionuclides and hazardous chemicals in the environment. Dr. Kocher's work on assessing the biological effectiveness of different radiation types and their uncertainties was an important contribution to the development of the Interactive Radio-Epidemiological Program, and he was principal investigator on work for the Defense Threat Reduction Agency to develop improved models and methods of uncertainty analysis for use in dose reconstructions. Dr. Kocher has served on several advisory groups for Federal agencies and on committees of the National Academy of Sciences (NAS) and NCRP, including committees that produced an NAS report on "A Review of the Dose Reconstruction Program of the Defense Threat Reduction Agency" and committees that produced NCRP reports on "Risk-Based Classification of Radioactive and Hazardous Chemical Wastes" (Report No. 139), "Approaches to Risk Management in Remediation of Radioactively Contaminated Sites" (Report No. 146), and "Performance Assessment of Near-Surface Disposal Facilities for Low-Level Radioactive Waste" (Report No. 152). He also was a member of a committee of the U.S. Department of Energy (DOE) that produced a DOE Standard on "A Graded Approach for Evaluating Radiation Doses to Aquatic and Terrestrial Biota." Dr. Kocher has been a frequent consultant to the International Atomic Energy Agency on issues of radioactive and hazardous chemical waste management and protection of the environment. |
![]() Kiyohiko Mabuchi
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![]() JEROME S. PUSKIN![]() is the Director for the Center of Science and Technology in the Radiation Protection Division, U.S. Environmental Protection Agency (EPA). He has been at EPA since 1985, heading a group with responsibility for developing models for EPA's assessment of radiation doses and risks. From 1982 to 1998, he worked on similar issues at the U.S. Nuclear Regulatory Commission (NRC). Prior to this, he was first a Postdoctoral Fellow and then a faculty member in the Department of Radiation Biology and Biophysics at the University of Rochester, where he performed research on ion transport into mitochondria and ion binding to phospholipid membranes. His academic degrees include a BA from Johns Hopkins and a PhD from Harvard, both in Physics. He has represented EPA on a number of interagency committees, including a committee established to advise on health protection measures for the U.S. population after Chernobyl and the Executive Committees for the Committee on Interagency Radiation Research and Policy Coordination and the Joint Coordinating Committee for Radiation Effects Research. He served on the scientific committee (SC) for NCRP Report No. 160, Ionizing Radiation Exposure of the Population of the United States and is currently a member of the NCRP SC 1-20, which is addressing the issue of enhanced relative biological effectiveness for low-energy photons and electrons. He was also a member of a committee of experts who developed the "Late Health Effects Uncertainty Assessment" component for the Probability Accident Consequence Uncertainty Analysis, a joint report of NRC and the Commission of the European Communities. |
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![]() Eliseo Vano
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![]() MARVIN ROSENSTEIN![]() is a consultant, currently concentrating on the preparation of scientific reports produced by NCRP in all subject areas. From 1982 to 1995, he was Director, Office of Health Physics at the Center for Devices and Radiological Health, U.S. Food and Drug Administration. He also served in a number of scientific and management positions related to radiation protection during his 33 y career as a Commissioned Officer in the U.S. Public Health Service, from 1962 to 1995. He received a BS in Chemical Engineering (University of Maryland, 1961), an MS in Environmental Engineering (Rensselaer Polytechnic Institute, 1966) and a PhD in Nuclear Engineering (University of Maryland, 1971). His technical work has concentrated on radiation dosimetry, particularly with regard to x rays used for medical diagnosis, epidemiological studies of exposed populations, and public radiation emergencies. He is a Distinguished Emeritus Member of NCRP (after serving as a Council member for 18 y), and an Emeritus member of Committee 3 (Protection in Medicine) of the International Commission on Radiological Protection [after serving on Committee 3 for 28 y (1985 to 2013)]. He was also a member of the International Commission on Radiation Units and Measurements report committee that produced Report 74, Patient Dosimetry for X Rays Used in Medical Imaging. |