Report No. 150 – Extrapolation of Radiation-Induced Cancer Risks from Nonhuman Experimental Systems to Humans (2005)

Product Details

Sort Title : Report No. 150

ISBN : ISBN 0-929600-86-X

Scientific Committee :

  • David G. Hoel, Chairman
  • Bruce A. Carnes
  • Robert L. Dedrick
  • R.J. Michael Fry
  • Douglas Grahn
  • William C. Griffith
  • Peter G. Groer
  • R. Julian Preston

  • Consultants
  • Kelly H. Clifton
  • Scott C. Miller
  • Hildegard M. Shuller
  • Thomas M. Seed

Executive Summary

This Report reviews the scientific issues associated with the extrapolation of radiation-induced cancer risks from nonhuman experimental systems to humans. The basic principles of radiation effects at the molecular and cellular level are examined with emphasis on comparisons among various species including humans. These comparisons among species are then continued for cancers of similar cell types in the same organ system. Risk estimates are made from an observed level of effect as a function of organ dose. The major organ systems are individually considered. Extrapolation models are reviewed and include external and internal radiation exposures.

Excerpts and Related Information

Table of Contents
Preface

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